In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen
نویسندگان
چکیده
منابع مشابه
Preparation, characterization, and dissolution studies of naproxen solid dispersions using polyethylene glycol 6000 and labrafil M2130
Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...
متن کاملReview: a single dose of oral naproxen or naproxen sodium reduced acute postoperative pain in adults.
Mason L, Edwards JE, Moore RA, et al. Single dose oral naproxen and naproxen sodium for acute postoperative pain. Cochrane Database Syst Rev 2004;(4):CD004234. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
متن کاملتاثیر گلوسیر 13/50 بر سرعت آزاد شدن ناپروکسن از پراکندگی های جامد تهیه شده با پلی اتیلن گلیکول 4000
Background and purpose: Solubility behavior of a drug is one of the key determinants of its oral bioavailability. The bioavailability may be enhanced by increasing the solubility and dissolution rate of drug by combining the drug with a hydrophilic carrier. Naproxen is a poor water non-soluble analgesic and anti- inflammatory drug. A possible way of overcoming the naproxen low aqueous solubilit...
متن کاملThe impact of liposomes on transdermal permeation of naproxen--in vitro studies.
The possibility of applying liposomes as a topical drug delivery system is still a matter of intensive research. The purpose of this study was to determine the suitability of liposomes as carriers of naproxen and to prove their impact on the effectiveness of transdermal permeation of an active substance. The study was conducted with the use of Franz Diffusion Cell System by comparing the effica...
متن کاملEnantioselective hydrolysis of racemic naproxen nitrile and naproxen amide to S-naproxen by new bacterial isolates.
Bacteria were enriched from soil samples with succinate as a carbon source and racemic naproxen nitrile [2-(6-methoxy-2-naphthyl)propionitrile] as sole source of nitrogen. Since naproxen nitrile was only poorly soluble in water media amended with different water-immiscible organic phases were used for the enrichments. With pristane (2,6,10,14-tetramethylpentadecane) as the organic phase two bac...
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ژورنال
عنوان ژورنال: International Journal of Medical Nano Research
سال: 2018
ISSN: 2378-3664
DOI: 10.23937/2378-3664/1410023